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Our data show extensive epigenetic remodeling in lipedema adipose tissue, with over 5,000 differentially methylated CpG sites affecting pathways related to receptor tyrosine kinase signaling, immune regulation, and phospho-metabolism

[DOI] [PubMed] [Google Scholar] 14.Jurima-Romet M, Barber RF, Demeester J, Shek PN

J Funct Foods 24:122130 [Google Scholar] Perez C, Sanchez J, Marmol F, Puig-Parellada P, Pouplana R (2007) Reactivity of biologically important NSAID compounds with superoxide (O2 . ), nitric oxide (

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FIGURE 1 In light of the increasing interest in natural medicine for the management of NDs, curcumin has garnered extensive attention as a highly promising therapeutic agent