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[115] described that phosphoglycerate dehydrogenase (PHGDH), involved in the synthesis of serine and glycine from glucose, is critical for pancreatic tumor cells proliferation and tumorigenesis, mediating cell-tight junctions formation, mTOR activation (through Akt), and protein expression and translation, after interaction with the translation initiation factors eIF4A1 and eIF4E (which seems to be independent of its enzymatic activity)

Metabolic changes that show up in bloodwork (better fasting glucose, improved A1c, lower triglycerides) take 6 to 8 weeks to register

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Recognizing the symptoms, understanding the timeline, and using supportive strategies can ease the journey and lead to better outcomes