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The number and size of mitochondria change according to the cellular metabolic and physiologic conditions

Modes of action against cancer cells including: inducing apoptosis by cytochrome c release, direct cell membrane lysis (necrosis), inhibiting angiogenesis, inducing autophagy-mediated cell death and immune cell regulation

Chin Med J 132(1):106108 Hu Y, Ma X (2021) Icariin treatment protects against gentamicin-induced ototoxicity via activation of the AMPK-SIRT3 pathway

Tendon repair: The Journal of Applied Physiology study cited earlier confirmed its direct action on tendon fibroblasts, supporting faster tendon healing in preclinical models (Chang et al., 2011)

Currently, there is no established standard treatment for acute and steroid-refractory GVHD (SR-aGVHD) (104, 105)

Prodrugs of GST Both conventional chemotherapeutic and targeted agents have well-established toxicity profiles, with a wide range of adverse effects, eg, bone-marrow suppression, gastrointestinal toxicity, immunosuppression, gastrointestinal toxicity, hepatotoxicity, and cardiotoxicity