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The different hGSTP1-1 mutants show slightly altered regioselectivities in the formation of the individual GSH conjugates of clozapine which suggests that the binding orientation of the reactive nitrenium ion of clozapine is affected by the mutations [34]

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doi: 10.1006/bbrc.1997.6697

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Receptor binding activates and increases the level of intracellular cyclic adenosine monophosphate in pancreatic cells, thereby stimulating insulin secretion glucose-dependently