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The role of glutamate neurotransmitter and the development of PIPN was confirmed in rat models where the co-administration of valproate suppressed glutamate accumulation and paclitaxel-induced mechanical allodynia [34]

This susceptibility hinges on the presence of an ether bond at the sn-1 position of the glycerol backbone of ether phospholipids, which is more vulnerable to ROS assault than the ester bond found in other typical phospholipids [125, 126]

10.1186/s12967-023-04166-8 124 YangC.HeX.ZhaoJ.HuangW

The subcutaneous route is still used, and it has some practical advantages

However, other constitutive promoter sequences may also be used, including, but not limited to the simian vims 40 (SV40) early promoter, mouse mammary tumor virus (MMTV), human immunodeficiency virus (HIV) long terminal repeat (LTR) promoter, MoMuLV promoter, an avian leukemia virus promoter, an Epstein-Barr virus immediate early promoter, a Rous sarcoma virus promoter, as well as human gene promoters such as, but not limited to, the actin promoter, the myosin promoter, the hemoglobin promoter, and the creatine kinase promoter

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