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Diabetes 38 , 673678 (1989)

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The target genes of p53 involve the canonical ferroptosis pathway of GSH metabolism (e.g., SLC7A11), iron metabolism (TfR1 and SLC25A28), lipid metabolism, ROS generation, several oxidation/reduction related proteins, and the non-canonical ferroptosis pathway (66, 67)

[DOI] [PMC free article] [PubMed] [Google Scholar] [2].Kumar A, Narayan RK, Prasoon P, Kumari C, Kaur G, Kumar S, et al

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Metal ions are very important in the first step of lipid autoxidation - the initiation process - in catalyzing the formation of reactive oxygen species as for example the hydroxyl radical (OH)