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Inhibition of serine biosynthesis through CRISPR- Cas9 -mediated knockout of PHGDH resulted in a ~250-fold reduction in the half-maximal inhibitory concentration (IC 50 ) for Rylaze, indicating heightened sensitivity to crisantaspase therapy

Enhancing the levels of glutathione and other metabolites in the trans-sulfuration pathway could have potential benefits for children with autism

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