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confirmed that nicotine exposure, a key product of cigarettes, triggered oxidative stress in pancreatic stellate cells via induction of the mitochondrial dynamics towards fission as shown by upregulation of Drp1 and smaller, fragmented-shaped mitochondria

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As dimerization reduces free Cys-34 residues, it adversely affects the antioxidant and binding capacity of HSA (Table I) (109)

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