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demonstrated that the use of dexmedetomidine during the perioperative period can decrease the mortality rate, the occurrence of postoperative complications, and the rate of delirium in patients undergoing cardiac operations [48]

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Patients were to be randomized to 1200 mg, 450 mg, or placebo, administered intravenously daily for 3 days followed by weekly for 4 weeks

Recently, therapeutic strategies aiming to combine host-directed therapies with pathogen-directed treatments have been developed, minimizing drug toxicity while attempting to reduce antimicrobial drug resistance [48,49,50]