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The safety evidence is assuring

In addition, it can reduce the release of inflammatory cytokines, including COX-2, prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and nitric oxide (NO), by inhibiting the NF-B pathway

Zdori, Semmelweis University, Hungary Updates Copyright 2021 Seiwerth, Milavic, Vukojevic, Gojkovic, Krezic, Vuletic, Pavlov, Petrovic, Sikiric, Vranes, Prtoric, Zizek, Durasin, Dobric, Staresinic, Strbe, Knezevic, Sola, Kokot, Sever, Lovric, Skrtic, Blagaic and Sikiric

D. C. Morris, M. Chopp, L. Zhang, and Z. G. Zhang, Thymosin 4: a candidate for treatment of stroke?, Wiley, May 2010. doi: 10.1111/j.1749-6632.2010.05469.x

Clinical studies show significant reduction in pigmentation intensity after 12 weeks of consistent use, with some users seeing improvements as early as 4-6 weeks

Results vary by individual, but most patients notice visible improvement after 46 sessions , with optimal results achieved through a full treatment course