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A study in mice suggested that coadministration of chlorpropamide or tolbutamide with alcohol resulted in inhibition of ALDH2, chlorpropamide being relatively more potent

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Activation of CB1R by THC disrupts the balance between excitatory and inhibitory neurotransmission, particularly affecting GABAergic and glutamatergic systems (Castelli et al., 2023a

Exendin-4 attenuates pain-induced cognitive impairment by alleviating hippocampal neuroinflammation in a rat model of spinal nerve ligation

The predominant oxylipins include AA derivatives like prostaglandins, thromboxanes, and leukotrienes ( Specialized pro-resolving mediators (SPMs) are a class of PUFA-derived lipid mediators ( Astrocytes, which hold about 1012% of the brains DHA, alongside oligodendrocytes and microglia, which account for 5% and 2%, respectively ( 5.2 Mitochondrial stability and antioxidant effects Although the effects of omega-3 PUFAs on ROS production within mitochondria have yielded mixed results, omega-3 PUFAs are known to influence mitochondrial function in several ways, including impacts on membrane potential, respiration rates, the activity of mitochondrial complexes, and ROS production

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