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Using endogenous antioxidant above may have already given away the answer

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Semaglutide, an FDA-approved injectable, helps curb appetite and aids in gradual weight loss

found that overexpression of an alternative translation product of ARF (p19), namely, short mitochondrial ARF (smARF), led to an abnormal mitochondrial membrane potential and promoted mitophagy-mediated ADCD [58]

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It is likely that such commonality in the responses, with diverse noxious events [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25] (as the cytoprotection concept posits for cytoprotective agents [35,36]), can suggest the equal efficacy of this therapy that should be demonstrated in the later course as well [6,30,31,32,33,34]