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473,474 AMPK activate peroxisome proliferator-activated receptor coactivator-1 (PGC-1), the key factor in mitochondrial biogenesis, thus enhancing mitochondrial respiratory and metabolic functions

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doi: 10.1038/cddis.2016.490 61 TanMMaoJZhengJMengYLiJHaoJet al

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The fact that specific regions of the nervous system exhibit differential vulnerabilities to aging and various neurodegenerative diseases is a reflection of both the specificity in the aetiology of each disease and of the heterogeneity in neuronal (and non-neuronal) responses to cell-damaging processes associated with each of the diseases [3]