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Under stress conditions, PINK1 promotes Parkin recruitment to the OMM to ubiquitinate mitochondrial proteins and polyubiquitin chains are subsequently phosphorylated by PINK1 as an initiation signal for autophagy

Complementing this, cell-based therapies, particularly the transplantation of stem cell-derived retinal pigment epithelium (RPE), aim to address the underlying cellular dysfunction in diseases like AMD, offering the potential to stabilize and perhaps restore retinal structure (Sakai et al., 2025)