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Clinical trials tested doses up to 1mg daily without significant adverse effects, but this does not mean higher doses produce better results or that exceeding researched doses is safe

NAD metabolism: Implications in aging and longevity

The key distinction: an NNMT inhibitor raises NAD+ indirectly, by protecting its raw material, rather than supplying it directly the way an NMN or NR supplement does

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(Picard et al., 2004) observed that overweight and obese patients could activate Sirtuin 1 (SIRT1) and Peroxisome proliferator-activated receptors (PPAR) through NAD + supplementation, resulting in weakened adipogenesis