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What makes some vaccines more painful than others, and some not hurt at all?

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It is used in research examining somatotropic signaling and peptide-receptor interactions in vitro

Negre-Salvayre A., Auge N., Ayala V., Basaga H., Boada J., Brenke R., Chapple S., Cohen G., Feher J., Grune T., Lengyel G., Mann G