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Tumour-educated macrophages promote tumour progression and metastasis

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This section aims to provide a detailed account of the experimental study on the further investigation is required to elucidate the crosstalk between PINK1/parkin-mediated mitophagy and mitochondrial biogenesis, with the involvement of PGC-1

In a similar study, the pivotal role for the IGF-1 in insulin sensitivity has received further support from liver-specific IGF-1 KO mice which exhibited overt insulin resistance and hyperinsulinaemia that was reversed by the administration of IGF-1 [161]