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Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation

Genes associated with adipogenesis and lipogenesis, including adiponectin, C1Q, and collagen domain containing ( ADIPOQ ), cluster of differentiation 36 ( CD36 ), FABP4 , fatty acid binding protein 5 ( FABP5 ), LPL , stearoyl-CoA desaturase ( SCD ), perilipin 1 ( PLIN1 ), cell death-inducing DNA fragmentation factor-like effector C ( CIDEC ), and peroxisome proliferator activated receptor ( PPARG ), as well as genes related to steroid biosynthesis, including 24-dehydrocholesterol reductase ( DHCR24 ), lanosterol synthase ( LSS ), methylsterol monooxygenase 1 ( MSMO1 ), NAD(P)-dependent steroid dehydrogenase-like ( NSDHL ), and cholesterol 25-hydroxylase ( CH25H ), were shown to be associated with high TG content in breast muscles [39]

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Detailed medical history was taken with special emphasis on age of onset and duration of the disease, frequency of epileptic attacks and number of hospital admissions due to severe attacks, as well as history of antiepileptic drugs (AEDs) (drug name, number of drugs, dosage, and duration of therapy)

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