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The sulfa antibiotics work by inhibiting bacterial growth and proliferation rather than killing bacteria

ROS can regulate NF-B via multiple mechanisms, and ROS induced NF-B activation has been well described (Whitehead et al

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mPTP: mitochondrial permeability transition pore

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Translational challenges to clinical practice include the heterogeneity of patient population in clinical trials, the presence of co-morbidities or medications that can affect ischaemic injury, variation in the duration of ischaemia and time of reperfusion, and the presence of adverse effects of newly developed therapies on other organs or systems [88,119]