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Acknowledgements The authors thank the many pioneers in the field and colleagues whose work has shaped current understanding of ferroptosis

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That is not a fringe concern it is the explicit worry of experienced former FDA officials who have spent careers building the evaluation standards that protect patients

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As the global population ages, the occurrence of cardiovascular diseases is mostly increasing, leading to a large requirement for effective treatments, which develops a major opportunity for senolytic drugs, that could provide new ways to manage & potentially reverse some of the damage caused by aging in cardiovascular health