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In the PubMed database, we used the following search query: (((Ubiquinone(MeSH)) OR (Coenzyme Q*(tw))) AND ((Dietary Supplements (MeSH)) OR (supplement*(tw)))) AND (randomized controlled trials as topic(MeSH))

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In the early stages, apoptosis is marked by cell shrinkage, chromatin pyknosis (condensation), a reduction in cell volume and an increase in cytoplasmic density, along with more compact organelles (101,104)

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