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The same was observed in clinical CD patients and in trinitrobenzene sulfonic acid (TNBS)-induced experimental colitis: increased expression of ACSL4/MDA/PTGS2/iron and inhibition of GPX4, which was ameliorated by treatment with Ferr-1 (63)

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A dysregulation of brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimers disease [2] through interference with the amyloidogenic A pathway [3], impairment of cerebral blood flow [4], and other mechanisms [5]

When studies reported multiple brain regions or several blood components (plasma, serum, blood cells), each region or component was extracted as a sub-study

Biol Psychiatry 78:702710 Pearce R, Owen A, Daniel S, Jenner P, Marsden C (1997) Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease

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