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385 Another novel proteasome inhibitor, CEP-18770, demonstrates superior and more sustained dose-dependent suppression of tumor proteasome activity than Bortezomib in medulloblastoma
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These should complement, not replace, the dietary and titration strategies discussed above

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Within the H-site, the substrate analogue ( 12 ) interacts through hydrogen bonds to N108 and the backbone of V12, a interaction with F112, water bridges to R16 and Y175, and hydrophobic interactions with V12 and V115 (Fig
