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Pirfenidone, an approved IPF antifibrotic, indirectly inhibits TGF1mediated epithelial-mesenchymal transitions by suppressing MUC1CT phosphorylation and catenin signaling, reducing SMA and collagen expression in preclinical models (166)

[DOI] [PMC free article] [PubMed] [Google Scholar] 127.Li W., Henderson L.J., Major E.O., Al-Harthi L

Ipsen filed a resubmission a few months later, which the FDA rejected in December 2022 and requested additional information regarding the data that the company had already provided

Noncanonical inflammasome activation by intracellular LPS independent of TLR4

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