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Mechanistically, it was revealed that glutamine uptake effectively increased the concentration of tumor glutamine and its downstream metabolite -KG, which drove hypomethylation of H3K4me3 via JmjC-containing KDMs, resulting in the downregulation of epigenetically activated oncogenic pathways [89]
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Sleep Med 107:289299
Tetsuro Ishii, University of Tsukuba, Japan Copyright 2014 Berndt, Lillig and Floh
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I105V polymorphism and promoter methylation of the GSTP1 gene in prostate adenocarcinoma
