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Similarly, folate requirements rise during active cell division, and inadequate folate can limit the effectiveness of B12 therapy

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Its research profile makes it relevant to controlled investigations involving methylation-linked metabolism, energy-balance signaling, metabolic stress response, adipose-associated cellular systems, and cellular adaptation under nutrient-sensitive conditions

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Summary Keywords endocrinology, growth hormone secretagogues, IGF-1 analogues, off-label use, peptide hormones, performance-enhancing drugs, sports doping Citation Dominikowski A, Rko Z, Olejarz M, Szczepanek-Parulska E, Domin R and Ruchaa M (2026) The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration