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Proto-porphyrin pigment in liver of rats and mice is mainly found in the bile ducts and leads to bile duct proliferation and portal inflammation, but can also occur in hepatocytes, Kupffer cells, and portal macrophages (Hurst and Paget 1963)

It is sold almost exclusively online as an unregulated "research chemical" labeled "not for human consumption," a designation sellers use to avoid marketing it as an illegal supplement or drug

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For example, if a product claims to "boost immunity," it must have evidence to support that claim, usually approved by the European Food Safety Authority (EFSA)

Synthesis of aldosterone requires aldosterone synthase and synthesis of cortisol requires 11beta hydroxylase