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However, over the years, large-scale clinical trials proved only limited health benefits of taking antioxidants (Halliwell 2022)

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In lamb studies with PPHN model, decreasing PaO 2 below 45 to 50 mm Hg results in increased PVR in newborn calves and lambs, and maintaining PaO 2 above 80 mm Hg does not result in any additional decrease in PVR (47, 58)