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This balance is achieved by sphingolipid synthesis and degradation, performed by lysosomal hydrolases, such as sphingomyelinase, which catalyzes the degradation of sphingomyelin into ceramide and phosphorylcholine, and acid -glucosidase (GBA1), which hydrolyzes glucosylceramide into ceramide and glucose

11 As the patient will continue these medications for a prolonged period of time with a need for titration, patients should be encouraged to follow up closely with primary care

Frequency of Administration: The Fifth Key Guideline The frequency of B12 injections is key to effective treatment

doi: 10.1016/j.athoracsur.2008.09.026 [DOI] [PubMed] [Google Scholar] 49.Wang G, Bainbridge D, Martin J, et al

130 MareV.StremeovJ.LisV.KozkovH.MarekJ.SyrekM.et al (2012)

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