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Dysregulated glutamate transporter SLC1A1 propels cystine uptake via Xc(-) for glutathione synthesis in lung cancer

doi: 10.1177/0004867419835028

Experimental parameters vary based on: Route of administration Study duration Target tissue or system Study designs often focus on: Oxidative stress biomarkers Detoxification pathways Mitochondrial function and cellular metabolism General Research Considerations: Concentration and exposure time should be optimized for each experimental system Redox-active compounds may exhibit dose-dependent effects , including pro-oxidant behavior at high concentrations Stability of glutathione in solution should be considered when designing experiments Important: All experimental use must be conducted in accordance with institutional and ethical research guidelines

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Andreeva, L