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Moreover, the proposed involvement of receptor-mediated signaling and phosphatidylserine oxidation should be considered as hypothesis-generating, since these mechanisms were not directly examined in the present study

78 A clinically useful biomarker should have specificity for a certain disease (diagnostic), have a prognostic value, and correlate with disease activity

Its prevalence has risen dramatically since 1980, when it was a perplexing and sporadically-observed disease as first reported by Ludwig and colleagues (1), to a current estimated 25% global prevalence.(2) NAFLD represents the leading cause of chronic liver disease and is the second leading indication for liver transplantation in the United States.(3) Its rise parallels the obesity epidemic and is attributed to the concomitant rise in the prevalence of type 2 diabetes and metabolic syndrome

The application of GR inhibitors, already reported to have positive outcomes for tumor, cancer, and parasite control [40,41,42], shows promise for a broad range of bacteria due to their universal reliance on GR for managing oxidative stress