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In comparison to the values observed after the first dose, the maximum plasma concentration (Cmax) increased by 3.974.88 times and the area under the curve (AUC 0 28 d) increased by 6.337.04 times

Thus, the potential for reducing therapeutic exposure to healthy cells in other systemic organs, as well as the local administration of reduced doses of the active ingredients to lung tissues and a reduction in adverse effects, represent advantages of administering drugs via the pulmonary route for the treatment of lung cancer [30,105]

doi: 10.1016/j.tcb.2018.06.006 57

Under hyperglycemic conditions, ROS accumulation within mitochondria directly leads to mitochondrial dysfunction

95% CI 1.2-0.2

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