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These enzymes insert Co 2+ into sirohydrochlorin to generate Co(II)-sirohydrochlorin but are structurally related to the iron-inserting enzyme SirB that converts sirohydrochlorin into siroheme [157,163,164], as well as to CbfA, which is the nickel chelatase that inserts Ni(II) into sirohydrochlorin for coenzyme F 430 biosynthesis [165,166]

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