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This condition can be emotionally devastating for the person experiencing it, and is often followed by feelings of low self-esteem or depression

C 117:111314

The National Cancer Institute acknowledges that high-dose IVC has demonstrated antitumor activity in preclinical studies and is being investigated in clinical trials

J Pharmacol Exp Ther 326: 196208, 2008

57,81,84 This close connection between the gut and the brain has been described as the gut-brain axis, and the gut microbiome and gut-associated neurons have been referred to as the second-brain. 85 5 Diagnosis Diagnosing anxiety disorders involves screening through careful history-taking, ruling out other causes of anxious symptoms, and use of diagnostic surveys

In patients taking opioids for an extended period of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper [see DOSAGE AND ADMINISTRATION, and WARNINGS]
