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GSH levels and their related enzyme activities, such as the activities of GPx and GR, are higher in cultured microglia than in cultured astrocytes and neurons, especially under oxidative stress conditions [85,86]

Journal of Alzheimer's Disease

Native peptide drugs, however, are generally ineffective when given orally due to low oral bioavailability, which is as a result of the physical and biochemical barriers of the gastrointestinal tract (GIT), often forcing the use of invasive parental delivery methods that lead to low patient compliance [3,4]

for example, the TLR4/NF-B/IL-1 signaling pathway is activated in chronic SZ patients (197), and clozapine reduces the expression of pro-inflammatory genes such as IL-1 and IL-6 by inhibiting the TLR4/NF-B pathway (198)

10.1016/j.bbi.2012.12.011 Brain Behav

Die Dosierung wird dann auf der Basis einer Blutuntersuchung festgelegt, bei der ein spezialisiertes Labor den intrazellulren Glutathion-Spiegel (also die Menge an GSH innerhalb der Zellen) feststellt