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Many mechanisms have been proposed to explain MDR, such as the decrease in intracellular drug concentrations due to efflux pump induction, the mutation of drug targets, the upregulated metabolic detoxification, and the enhanced DNA damage repair function [63]

The molecular mechanism of NADPH homeostasis in cancer cells is complex and involves several key pathways and enzymes (Ju et al

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

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These substances mainly include some antioxidant enzymes, oxidase inhibitors, vitamins C and E, some metal ions such as Se and Zn, and some hormones

Fagervall I, Ross SB