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Further investigations on the immune metabolism of different immune cells in orbital tissues, as well as the regulatory function of OFs and CD34 + fibrocytes in immune metabolism, can enhance the understanding of the development and pathogenesis of TED

Indeed, there were notable differences in immune microenvironment composition, immune checkpoint gene expression, and chemotherapy response between the two risk groups (220)

An animal study has revealed that dietary supplementation with I3C notably alters the metabolic profile of mouse prostate tissue, involving reprogramming of intermediates related to glycolysis, the tricarboxylic acid cycle and lipid metabolism (85)

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Notably, the WD-DSS group exhibited higher gray values for these proteins compared to the LD-DSS group, suggesting that dysregulated lipid metabolism may exacerbate the inflammatory response