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Systemic inflammation is found in COPD patients and negatively affects co-occurring disorders such as diabetes, cardiovascular diseases, and osteoporosis (Barnes 2016)
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CD8 + cytotoxic T lymphocytes mediate direct thyrocyte lysis via perforin, granzymes, and proteoglycans, and are recruited and activated by autoreactive CD4 + T cells through IL-12 and IFN- signaling

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