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NNMT inhibition or NNMT knockdown improves insulin sensitivity and normalizes glucose tolerance and fasting blood glucose levels [14], but the mechanisms by which NNMT regulates insulin sensitivity and blood glucose homeostasis are unclear

Critically, AOD-9604 did not produce the metabolic side effects associated with full-length growth hormone, including no insulin resistance or glucose intolerance, no elevation of IGF-1 levels, no fluid retention or joint pain, and no cardiovascular parameter changes

doi: 10.1530/EJE-22-0440 65 McCormackADekkersOMPetersennSPopovicVTrouillasJRaverotGet al

These are not routine for every patient
