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Blood, along with its liquid components, plasma or serum, is one of the most extensively studied sample types in metabolomics across various diseases because it mirrors systemic pathophysiological processes and provides a snapshot of metabolic changes influenced by factors such as age, sex, lifestyle (e.g., exercise, smoking, diet), genotype, medication, environmental factors, and others 21

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Those who did not see any improvement may not have been dosed adequately, as the dosage of Betaine with Pepsin should be individualized