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As cannabis becomes legalized and more widely accepted, and as we understand that you can be tolerant and have physical or psychological withdrawal from many medicines without necessarily being addicted to them (such as opiates, benzodiazepines, and some antidepressants), I think this definition seems obsolete and overly inclusive

S., Manfredini, V., de Mari, J

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While other reports exclude that CAC could be regulated by PPAR factors ( Implications of CAC in Cancer To date, the correlation between CAC and cancer has received little attention, and only a few studies have reported a link between the altered expression of CAC and cancer (Table 1)

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