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Later 2019 rat study showed that Gotu Kola directly combats stress-induced inflammation in the brain

aureus utilize surface proteins (e.g., ClfA and fibronectin-binding proteins) to adhere to host cells and tissues, which is a critical step in colonization

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In addition, gliotoxin can ameliorate trinitrobenzene sulfonic acid (TNBS)-induced mouse colitis via the suppression of the expression levels of TNF-, IL-1, and intercellular adhesion molecule-1 (ICAM-1) proteins as well as the upregulation of heme oxygenase-1, thus indicating the potential application of gliotoxins in the clinical treatment of Crohns disease [50] via the induction of hemooxygenase-1, which can oxidize low-density lipoproteins with the potential to form chemo-attractants, thus alleviating the inflammation [51]

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