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Necrosis (centrilobular, midzonal, periportal) might be accompanied by other histological changes (fatty change, congestion, hemorrhage, inflammation, bile stasis, fibrosis, etc.) to form a myriad of pathological changes

For example, dysregulated microRNAs alter granulosa-cell steroidogenesis and endometrial receptivity

The chronic deprivation of oxygen and nutrients even limits the therapeutic potential of strong growth-promoting factors in fully restoring growth or beta cell function, says Childrens Colorado neonatologist Alicia White, MD, lead author of the study

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These data indicate that exogenous iron overload-induced intracellular iron accumulation, which overwhelmed the iron overload response of RPE cells and initiated ferroptosis

[DOI] [PubMed] [Google Scholar] 69.Hayes J.D., Flanagan J.U., Jowsey I.R