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In people without diabetes, tirzepatide 5 to 15 mg once weekly for the treatment for obesity (SURMOUNT-1) resulted in substantial reductions in body weight (16.5% to 22.4%) over 72 weeks

According to a Clinicians Guide in a University of Virginia report published in 2018, the condition may not fully resolve for up to eight weeks, however (8) Neurologic symptoms, like tingling, numbness in hands and feet, or dizziness, generally improve in six to 12 weeks, and severe neurological symptoms, like difficulty walking, may not ever resolve completely

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Specifically, the T1R2-T1R3 heterodimeric receptor is involved in the activation of glucose-responsive neurons in the hypothalamus

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