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[DOI] [PubMed] [Google Scholar] 622.Caldirola D., Dacc S., Cuniberti F., Grassi M., Lorusso S., Diaferia G., Perna G
Though the group reported appreciable 1000:1 selectivity for hMC4R affinity compared to hMC1R affinity, functional cAMP assay results were only reported for hMC4R (EC 50 = 88 nM, E max = 85%), seen in Table 1 ( 50 = 31 nM, E max = 105%) but only had partial agonist activity at hMC3R (EC 50 = 39 nM, E max = 31%) ( Conde-Frieboes et al
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Hopefully, after reading this chapter, you will agree that this fundamental cellular process is as beautiful as it is complex
