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282, 1715717165.10.1074/jbc.M700804200 20 HibiT.NiiH.NakatsuT.KimuraA.KatoH.HiratakeJ.OdaJ

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Nrf2, a key transcription factor that regulates cellular antioxidant response, increases the expression of genes involved in the anti-oxidative defense system, such as GPX4 (64)

Eur J Med Chem (2015) 97:5574

In human cervical cancer Hela cells, overexpression of GSTP1 was shown to not only inhibit the activation of JNK, as described above but also activation of p38 by suppression of the tumor necrosis factor receptor-related factor 2 (TRAF2), thereby playing a key regulatory role in TNF--induced MAPK signal transduction [11,64]

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