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Animal models of inflammation for screening of anti-inflammatory drugs: Implications for the discovery and development of phytopharmaceuticals

Nat Rev Mol Cell Biol 22(4):266282 Zhao J, Wu Y, Zhou K et al (2023) Ferroptosis in calcium oxalate kidney stone formation and the possible regulatory mechanism of ANKRD1

In addition to external environmental factors, the internal exposomeincluding biological elements such as the gut microbiome, inflammation, and disease statesplays a crucial role in modulating CYP450 enzyme activity and drug metabolism
The antidote for Lewisite is British Anti-Lewisite (BAL), also known as Dimercaprol

10.1016/j.molcel.2018.10.042 117 GerhardD

Liver-related The following symptoms may indicate copper accumulation in the liver: weakness feeling tired weight loss nausea vomiting loss of appetite itching jaundice, or yellowing of the skin edema, or the swelling of legs and abdomen pain or bloating in the abdomen spider angiomas, or visible branch-like blood vessels on the skin muscle cramps Many of these symptoms, such as jaundice and edema, are the same for other conditions like liver and kidney failure
