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The is called the folate trap , and, as well as slowing down production of SAMe, it will also stop THF going back into the folate cycle, affecting folate levels

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doi: 10.1016/j.febslet.2008.04.038 230 MottilloEPDesjardinsEMFritzenAMZouVZCraneJDYabutJMet al
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[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Sovari A.A., Rutledge C.A., Jeong E.M., Dolmatova E., Arasu D., Liu H., Vahdani N., Gu L., Zandieh S., Xiao L., et al

The peptide is stable in stomach acid so it can be absorbed well in bloodstream even when taken by mouth
