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Pre-treatment of IVF patients with AOXs improved embryo quality, particularly in poor responders (219)

For the conjugation of Mn/TI@mHSA to cPLT, Mn/TI@mHSA NPs in PBS were first activated with sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate, then concentrated using Amicon ultra-centrifugal filters (molecular weight cut-off 50 kDa) with 3000 g for 10 min and washed with PBS to remove unreacted linker

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AI-driven analyses can uncover novel compounds and predict their senescence-modulating properties based on biological data.206 Moreover, systems biology approaches that analyze the complex networks of cellular aging processes could help uncover new targets for senomorphic therapies and optimize their clinical applications.207 Combination Therapies: Synergizing Senolytics and Senomorphics While both senolytics and senomorphics offer promising approaches for targeting cellular senescence, recent research suggests that combining these two therapeutic strategies may enhance their individual benefits, leading to more robust outcomes in promoting healthy aging