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Many authors have shown that CD is associated with an imbalance between increased ROS and decreased antioxidant activity, resulting in OxS phenomena (7, 11-15)

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In short, this article validates an innovative and promising strategy to control the action of PROTACs, in which introducing cleavable groups under certain physiological conditions helps to increase selectivity and consequently reduce off-target effects of PROTACs 118

see Ochoa-Herrera et al

These new findings further support to the use of B 12 supplementation especially in terms of delivering the vitamin to astrocytes within the brain while revealing that fingolimod can correct the impaired astrocyte-B12 pathway in people with MS